CCNP 26th Annual Meeting

All scientific sessions/activities will be held in the Marriott Chateau Champlain in Montréal, Québec.

Marriott Chateau Champlain*
1 Place du Canada, Montréal
Telephone (514)-878-9000
McCord Museum
690, Sherbrooke West, Montréal
(514) 398-5045

*Please note the the venue has changed from the Renaissance Hotel to the Marriott Chateau Champlain.

Sunday, June 01

12:00-17:00Registration (Foyer Cartier)
13:00-17:00CCNP Council Meeting (Maisonneuve C)
14:00-15:00Public Lecture (Cartier BC)
Dr. F. Xavier Castellanos (New York University, USA) - Brain growth and ADHD
18:00-21:00CCNP Welcoming Reception (McCord Museum)

Monday, June 02

08:00-17:00Registration (Foyer Cartier)
08:00-08:45Breakfast (Foyer Cartier)
08:45-09:00Opening Remarks (Cartier BC)
Sidney Kennedy, CCNP President
Lalit Srivastava, Chair - Local Organizing Committee
09:00-10:00Plenary Lecture (Cartier BC)
F. Xavier Castellanos (New York University, USA): Developmental trajectories of anatomic abnormalities in attention-deficit/hyperactivity disorder (ADHD)
10:00-10:30Coffee Break (Foyer Cartier)
10:30-12:30Symposium 1 - Eating Disorders: Neurobiological and Genetic Factors (Cartier A)

Chair: Howard Steiger (Douglas Hospital Research Centre/McGill University, Montréal)

Kelly Klump (Michigan State University, USA): Twin studies of eating disorders: genetic, environmental and developmental influences

Howard Steiger (Douglas Hospital Research Centre/McGill University, Montréal): Serotonin function in bulimia nervosa: neurobiological and genetic findings

Walter Kaye (Virginia Institute for Psychiatry & Behavioral Genetics, USA): Role of 5-HT1A and 5-HT2A receptor activity in symptoms of anorexia nervosa

Allan Kaplan (Toronto General Hospital, Toronto): New findings in the genetics of anorexia nervosa
10:30-12:30Symposium 2 - Neuropsychopharmacology of Motivation and Reward: Implications for Psychiatric Disorders (Cartier BC)

Co-Chairs: Pierre-Paul Rompré (Université de Montréal, Montréal) and Andrew Greenshaw (University of Alberta, Edmonton)

Roy Wise (NIH/NIDA/IRP, USA): Brain circuitry of drug reward

Pierre-Paul Rompré (Université de Montréal, Montréal): Neurotensin and behavioral sensitization to drugs of abuse

Marco Leyton (McGill University, Montréal): Alcohol, nicotine, amphetamine, and cocaine: PET/[11C]Raclopride and dopamine depletion studies in humans

Hans C. Breiter (MGH/Harvard University, USA): MRI studies of human reward circuitry responses to drug and non-drug stimuli
12:30-14:00Lunch (Foyer Cartier)
14:00-16:00Symposium 3 - On the Causes of Autsim, Rett Syndrome and Other Neurodevelopmental Disorders (Cartier A)

Co-Chairs: Ridha Joober (Douglas Hospital Research Centre/McGill University, Verdun) and Patricia Boksa (Douglas Hospital Research Centre/McGill University, Verdun)

Eric Fombonne (Montréal Children Hospital, Montréal): Epidemiological surveys of autism and pervasive developmental disorders

Matthew Tudor and Rudolf Jaenisch (Whitehead Institute for Biomedical Research, Massachusetts, USA): Mouse models for human Rett syndrome

Lonnie Zwaigenbaum (McMaster University, Hamilton): Genetics of autism: update and new directions

S.H. Fatemi (University of Minnesota Medical School, Minneapolis, USA): The role of Reelin in pathology of autism
14:00-16:00Symposium 4 - Neurosteroids, CNS Function and Mood Disorders (Cartier BC)

Co-Chairs: Alan Bateson (University of Leeds, UK) and Jean-Michel LeMellédo (University of Alberta, Edmonton)

Sheryl Smith (State University of New York Downstate Medical Center, USA): Neurosteroid-mediated changes in GABAA receptor subunit expression: effects on anxiety and hippocampal physiology

Alessandro Guidotti (Chicago, USA): Downregulation of neurosteroid biosynthesis and aggressive behaviour

Elena Romeo (Rome, Italy): Neuroactive steroids in mood disorders and Parkinson disease

Jean-Michel LeMellédo (University of Alberta, Edmonton): Neuroactive steroids and human anxiety
16:00-16:15Coffee Break (Foyer Cartier)
16:15-17:15Heinz Lehmann Award Lecture (Cartier BC)

Dr. Thérèse Di Paolo (Molecular Endocrinology & Oncology Research Centre,): Hormonal modulation and protection of brain neurotransmission: potential therapeutic application for schizophrenia and Parkinson's Disease
17:15-19:15Posters and Cash Bar (see end of program for listing of poster presenters) (Posters in Neufchatel Room)

Tuesday, June 03

08:00-17:00Registration (Foyer Cartier)
08:00-08:45Breakfast (Foyer Cartier)
08:45-10:45Symposium 5 - New Insights into the Mechanism of Antipsychotic Drug Action, the Dopamine D2 Receptor and Beyond (Cartier A)

Chair: Daniel Lévesque (Laval University, Ste-Foy)

Philip Seeman (University of Toronto, Toronto): The high-affinity state of the dopamine D2 receptor in the action of amphetamine, anesthetics, and atypical antipsychotics

Philip Strange (University of Reading, UK): Inverse agonism of the antipsychotic drugs at D2 dopamine receptors - relevance for antipsychotic action

Paul R. Albert (University of Ottawa, Ottawa): Dopamine-D2 receptors: novel aspects of signaling, regulation, and implications for schizophrenia

Daniel Lévesque (Laval University, Ste-Foy): Nuclear receptors: a new way of looking at antipsychotic drug effects
08:45-10:45Symposium 6 - Update on the Neurobiology of Suicide and Related Behaviours (Cartier BC)

Chair: Gustavo Turecki (Douglas Hospital/McGill University, Montréal)

Randy J. Nelson (Ohio State University, Columbus, USA): Using gene-knockout mice to understand aggression

Gustavo Turecki (Douglas Hospital/McGill University, Montréal): Gene changes in suicide: brain gene expression in suicide with and without major depression

John J. Mann (Columbia University, USA): Abnormalities in brain stem nuclei related to suicide or mood disorders

Marco Leyton (McGill University, Montréal): Brain regional a-[11C]methyl-L-tryptophan (a[11C]MTrp) trapping in suicide attempters
10:45-11:15Coffee Break (Foyer Cartier)
11:15-12:15Plenary Lecture (Cartier BC)
Helen Mayberg (Rotman Research Institute/Baycrest Centre, University of Toronto, Toronto): Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis
is and optimised treatment
12:15-14:00CCNP Business Meeting (Cartier A)
12:15-14:00Lunch (Foyer Cartier)
14:00-16:00Special Symposium: CCNP: The Next Generation (Cartier BC)

Sean Barrett (McGill University, Montréal): Examining concurrent drug and alcohol use: implications for the neuropsychopharmacology of alcohol addiction

Anna-Maria Biondo (University of Alberta, Edmonton): Supression of familiar food intake by wheel running in a model of activity anorexia

Glenn Legault (Trent University, Peterborough): Impairment of cholinergic or dopaminergic neurotransmission in the striatum during the proposed paradoxical sleep window leads to deficits in learning the radial arm maze in rats

Masami Nishikawa (McGill University, Montréal): Reduced human brain serotonin (5-HT) synthesis in depression using Positron Emission Tomography (PET) and a-[11C]Methyl-Tryptophan (a-MTrp)

Haiyun Xu (University of Saskatchewan, Saskatoon): Chronic venlafaxine accelerates the recovery of hippocampal neurons from restraint stress-induced changes

Peter Zwanzger (Institute of Mental Health Research, Ottawa): Impact of selective GABA-ergic treatment on experimental induced panic
16:00-16:15Coffee Break (Foyer Cartier)
16:15-18:15Poster Session II (Cash bar available) (Posters in Neufchatel Room)
19:00-Banquet (Ballroom)

Wednesday, June 04

08:00-11:00Registration (Foyer Cartier)
08:00-08:45Breakfast (Foyer Cartier)
08:45-09:45Young Investigator Award Lecture (Cartier BC)
Gustavo Turecki (Douglas Hospital/McGill University, Montréal)
Clinical and genetic studies of suicide and related behaviors
09:45-10:45Plenary Lecture (Cartier BC)
Charles P. O'Brien (University of Pennsylvania, USA): Translating basic research findings into improved medications for addiction
10:45-11:15Coffee Break (Foyer Cartier)
11:15-13:15Symposium 7 - Emerging Experimental Therapies for Alzheimer's Disease (Cartier B)

Chair: Judes Poirier (Centre for Studies in Aging/McGill University, Montréal)

Sultan Darvesh (Dalhousie University, Halifax): Butyrylcholinesterase as a potential target for the treatment of Alzheimer's disease

Judes Poirier (Centre for Studies in Aging/McGill University, Montréal): APO E, cholesterol lowering agents and HMG COA reductase in sporadic Alzheimer's Disease

Francine Gervais (): Targeting soluble amyloid beta for the development of disease-modifying therapeutics in Alzheimer's disease

Paul Aisen (Georgetown University Medical Center, USA): Can Alzheimer's Disease be successfully treated with anti-inflammatory drugs?
11:15-13:15Symposium 8 - Attention Deficit Hyperactivity Disorder: Selected Genes for Selected Behaviours (Cartier C)

Chair: Ridha Joober (Douglas Hospital/McGill University, Montréal)

Rosemary Tannock (The Hospital for Sick Children, University of Toronto, Toronto): Significance of inattention, gender, and working memory for genetic investigations of Attention-deficit/hyperactivity disorder

Gillian O'Driscoll (Douglas Hospital Research Centre/McGill University, Verdun): "Predictive saccades in attention deficit hyperactivity disorder

Susan L. Andersen (McLean Hospital & Harvard Medical School, USA): Early methylphenidate exposure and its relationship to drug abuse

Michael Gill (Trinity College, Ireland): In dopaminergic system genes in ADHD: towards a biological hypothesis
13:15-13:30Concluding Remarks (Cartier B)

This education event is approved as an Accredited Group Learning Activity under Section 1 of the Framework of CPD options for the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.


(Presenting author - in alphabetical order)

aan het Rot, M. - The influence of tryptophan depletion on decision-making in healthy first-degree relatives of bipolar patients and controls
aan het Rot, M. - Role of dopamine vs. Norepinephrine in effects of d-amphetamine: an acute phenylalanine/tyrosine depletion study in healthy men
Ahboucha, S. - Involvement of neurosteroid pathway in hepatic encephalopathy
Andreopoulos, M. - >Chronic lithium exposure reduces transient receptor channel (TRPC) 3 levels in b-lymphoblasts (BLCLs) from bipolar disorder (BD) patients
Ayoubi, M. - Amphetamine induced hyperlocomotion in recombinant congenic strains of mice and association with genetic markers
Barrett, S. - Examining concurrent drug and alcohol use: implications for the neuropsychopharmacology of alcohol addiction
Bauco, P. - Effect of neurotensin receptor activation on exploratory locomotion and thermoregulation in Fischer and Lewis rats: effects of cross-fostering
BenAmor, L. - The dopamine D4 receptor gene and response to methylphenidate in children with attention-deficit/hyperactivity disorder
Bermack, J. - The increased firing activity of serotonergic neurons by sigma ligands is not due to the 5-HT1A autoreceptor inactivation
Bezchlibnyk, Y. - Amygdala CREB phosphorylation in patients with mood disorders: effects of diagnosis, suicide and drug treatment
Bhardwaj, S. - Effects of amphetamine and antipsychotic treatments on neonatal ventral hippocampal lesion-induced changes in NGFI-B mRNA expression
Biondo, A. - Supression of familiar food intake by wheel running in a model of activity anorexia
Biondo, A. - Excessive wheel running by food restricted rats: a model of activity anorexia
Boksa, P. - Birth complications and dopamine function: a single dose of epinephrine at birth reverses long term increases in tyrosine caused by C-section birth in the rat
Bymaster, F. - The selective norepinephrine uptake inhibitor atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder
Carvajal, C. - Characterization of transgenic rats overexpressing hippocampal neuropeptide Y: implications for anxiety disorders
Casey, K. - Catecholamine depletion reduces nicotine withdrawal related craving but not self-administration in nicotine-dependent smokers
Chaudhry, A. - The novel circling mouse (Cr) from a transgenic growth hormone mouse colony shows behaviour associated with dysregulated striatal dopamine
Clements, R. - NMDA receptor antagonist MK-801 dose-dependently blocks conditioned place preference induced by dopamine D2/3 receptor stimulation, without producing conditioned locomotion in rats
Clements, R. - Differential effects of dopamine D2/3 receptor stimulation by 7-OH-DPAT or apomorphine on locomotor hyperactivity produced by NMDA receptor blockade
Dépatie, L. - Executive functions in attention deficit hyperactivity disorder
Dickson, R. - Sexual functioning, prolactin levels and psychopathology in an Olanzapine switch trial
Dumais, A. - Suicide in major depression: a case-control study of impulsive and impulsive-aggressive behaviors
Dumont, Y. - Characterization of neuropeptide Y Y2 receptor knockout mice in two animal models of learning and memory processing
Fortier, M-E. - Evaluation of LPS as a tool to study the effects of maternal infection during pregnancy in relation to schizophrenia
Garand, I. - Simultaneous poly-drug use patterns in >rave= attendees: implications for understanding mechanisms of drug action
Gauthier, J. - Autism and comorbidity: duplications on chromosome 7"
Gil, L. - Effects of the panicogenic agent, Pentagastrin, on plasma neuroactive steroid levels
Gobbi, G. - The mechanism of action of NK1 receptor antagonists: in vivo electrophysiological, behavioral and immunohistochemical studies in mutant mice
Han. Y-S. - Neuroprotective effects of resveratrol on ß-amyloid-induced neurotoxicity in rat cultured hippocampal neurons: involvement of protein kinase C pathways
Hasegawa, S. - CP-93,129, A 5-HT1B receptors agonist, reduces 5-HT synthesis acutely in the rat brain without having a chronic effect: an autoradiographic study
Kennedy, S. - Differences in sexual dysfunction between men and women with depression: a comparison of bupropion and paroxetine treatment
Kim, C. - A family study of suicide completion: preliminary results
Kim, C. - Seasonality in psychopathology of male suicides
Knott, V. - The a2-noradrenergic receptor agonist clonidine does not modify the acute smoking-induced EEG arousal/mood response profile
Kumar, N. - Behavioural and electrophysiological explorations of semantic dysfunctions in schizophrenia
Lal, S. - Devomepromazine vs chlorpromazine in treatment-resistant schizophrenia
Lalovic, A. - Serum cholesterol, suicidality, impulsivity and aggression in Smith-Lemli-Opitz syndrome heterozygotes
Legault, M. - Impairment of cholinergic or dopaminergic neurotransmission in the striatum during the proposed paradoxical sleep window leads to deficits in learning the radial arm maze in rats
Leri, F. - Modulation of motivational properties of cocaine by opioid dependence
Le Saux, M. - Effect of estrogenic compounds on membrane dopamine and vesicular monoamine transporters in ovariectomized rats
Lewis, R. - Cognitive deficits in adolescent schizophrenia versus affective psychosis
Leyton, M. - Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: a PET study in healthy men
Luo, C. - Olanzapine up-regulates BCL-2 and BDNF immunoreactivities in the hippocampal neurons of rats following repeated restraint stress
Mamdani, F. - Investigation of the frequency of 5 single nucleotide polymorphisms in the PREP gene in lithium treated bipolar subjects
Marcangione, C. - Characterization of a functional connection between the bed nucleus of the stria terminalis and the ventral tegmental area: significance for reward-relevant behavior
Marinelli, P. - A microdialysis profile of ß-endorphin and dopamine in the rat nucleus accumbens following alcohol administration
Mosher, T. - Effects of the 5-HT receptor agonists TFMPP and RU24969 on locomotor activity and place-preference conditioning: differential effects of the selective 5-HT2C receptor antagonist SB 242084 in rats
Mosier, K. - Does dose staggering significantly reduce drug-drug interaction between clozapine and fluvoxamine in dogs?
Mousseau, D. - Amyloid-ß promotes the interaction between the voltage-dependent anion channel, VDAC, and pro-apoptotic Bax
Naranjo, C. - Probing central serotonin function in alcohol dependence using acute tryptophan depletion
Neumark, E. - Mood and cardiovascular response to stress: effects of tryptophan depletion
NicNiocaill, B. - Evidence for GABA receptor regulation of globus pallidus glutamate release
Pazderka-Robinson, H. - Drug craving in humans correlates with affect and behaviour, but not cognition
Pradhan, A. - Comparison between delta opioid receptor density and agonist stimulated [35S]GTP?S binding in rat CNS
Prior, T. - Progesterone elevations related to symptom severity but not anxiety in first break schizophrenia
Ravindran, A. - Efficacy of sertraline in improving quality of life and functioning in generalized anxiety disorder (GAD)
Regoli, M. - Acute tryptophan depletion in MDMA abusers (Ecstasy)
Rittenbach, K. - Derivatization with pentafluorobenzenesulfonyl chloride followed by electron-capture gas chromatography for analysis of secondary amine tricyclic antiddepressants
Robichaud, M. - The allopregnanolone-induced increase in female serotonergic neuronal firing activity is not blocked by RU486"
Rotzinger, S. - TCAP-1, a novel, CRF-like neuropeptide is expressed in limbic brain regions and modulates acoustic startle response in rats
Sellings, L. - Anatomical segregation of rewarding and arousing effects of amphetamine in nucleus accumbens shell and corre subregions
Sequeira, A. - 5-HT1A receptor gene and suicide
Shah, A. - Dorsal and ventral medial prefrontal cortex infusions of the benzodiazepine midazolam attenuate anxiety-related behaviour in rodents
Shao, L. - Large scale gene expression analysis reveals regulation of glutathione s-transferase by chronic valproate treatment
Sowa, B. - Biochemical activity of 4-methoxy and 4-fluoro analogues of phenylethylidenehydrazine
Sowell, M. - Risk factors for diabetes during clinical trials of antipsychotics
Steiner, M. - Generalized anxiety disorder (GAD): gender differences in clinical presentation and response to sertraline
Stevenson, C. - Basolateral amygdala dopamine modulation of prepulse inhibition of the acoustic startle response in the rat
Taerk, E. - COMT VAL108/158 met polymorphism does not modulate executive functions in children with ADHD
Tarazi, F. - Selective serotonin/glutamate receptors mediate actions of newer antipsychotic agents
Tarazi, F. - Norepinephrine and serotonin transporters: targets for ADHD pharmacotherapy
Torkamanzehi, A. - Prepulse inhibition of tactile startle response in recombinant congenic strains of mice and association with genetic markers
Wang, H. - The M5 muscarinic receptor gene is at the 15q13-14 schizophrenia locus, and increases D2 gene expression in M5 knockout mice
Weiss, M. - Controlled study of once-daily atomoxetine in the school setting
Wilson, J. - Glutamate stimulates and sepsis inhibits the production of extracellular ascorbate from dehydroascorbic acid by astrocytes
Wolff, M. - An in vivo assessment of aripiprazole, ziprasidone, risperidone and olanzapine in rat assays indicative of 5-HT1A and D2 receptor activity
Xiong, L. - Association and linkage studies of the chromosome 13Q33 G72 and G30 schizophrenia susceptibility genes
Xiong, L. - CAA insertion polymorphism in the 3'-UTR of nogo gene on 2P14 is not associated with schizophrenia
Xu, H. - Chronic venlafaxine accelerates the recovery of hippocampal neurons from restraint stress-induced changes
Yeomans, J. - Improved latent inhibition learning in M5 muscarinic receptor knockout mice
Zhang, T. - Early maternal separation in the rat results in a potentiated dopamine response to stress in the right medial prefrontal cortex of adult offspring
Zwanzger, P. - Impact of selective GABA-ergic treatment on experimental induced panic
Zwanzger, P. - Repetitive transcranial magnetic stimulation (RTMS) in experimentally induced panic